We offer the widest product range of low-flow (mass) flow meters and controllers on the market. Numerous styles of both standard and bespoke instruments can be offered for applications in laboratory, machinery, industry and hazardous areas.
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Bronkhorst instruments are used for numerous applications in many different markets. In this section you will find an overview of the main markets for our equipment, illustrated with some typical examples of applications.
Are you looking for technical documentation, are you interested to learn more about the measuring principles of Bronkhorst products, or you do want to get in contact with a Bronkhorst Service Engineer? This section will guide you to the relevant service & support topics.
Bronkhorst High-Tech BV the leaders in Mass Flow Meter / Mass Flow Controller technology for gases and liquids, Pressure Controllers and Evaporation Systems.
For many years, Mass Flow Controllers (MFCs) and Mass Flow Meters (MFMs) have been used in Analytical instrumentation. There are some distinctive applications like carrier gas control or mobile phase control in Gas Chromatography (GC) and Liquid Chromatography (LC). I discovered that there are a lot more applications of Mass Flow Controllers in analyzers then I could imagine when entering the world of Mass Flow Controllers after many years working in Analytical Chemistry.
One application I would like to focus on in this blog is Mass Spectrometry or shortly, as chemists like to use abbreviations, MS. Mass Spectrometry comes in many forms and is often coupled to Gas Chromatography and Liquid Chromatography. A Mass Spectrometer coupled to a Gas Chromatography (GC) is called a GC-MS and a Mass Spectrometer coupled to a Liquid Chromatography (LC) is called a LC-MS.
The Mass Spectrometer is often compared with a weighing scale for molecules. Every molecule is built up from atoms and every atom has its own atomic mass and this is “weighted” by a Mass Spectrometer. Before it can weigh the different atoms that are present in one sample, the atoms have to be separated from each other. This is done by charging the atoms (to form ions) and using a magnet to deflect the path that the ion is following. The lighter the ion, the more influence the magnet has and the bigger the deflection. The detector detects where the ion hits and this is a measurement of the weight.
The place where the ionization takes place is called the ion source and there are a lot of different types of ion sources, depending on the matrix of the sample and on the ions that you want to form. The ionizing part is the most interesting part from a Mass Flow point of view because in this part different gases are used, depending on the technique of ionization.
There are two main techniques: hard ionization and soft ionization. With hard ionization techniques, molecules in the sample are heated and fragmented down to atomic levels giving information about the atomic structure of the molecule. With soft ionization techniques the molecule stays more intact giving mass information of the molecule. This is used in Food and Pharma research and has become very popular in the last decade.
Let’s look into detail to one of the most popular soft ionization techniques, the Electrospray Ion Source. The EIS vaporizes the liquid (coming from a Liquid Chromatograph, for example) by leading gas alongside a charged needle to form an aerosol spray. Leading a counter gas flow through the formed spray will evaporate most of the liquid that you do not want to measure, leaving the charged droplets going into the Mass Spectrometer.
The interesting part is that the flow needs to be very constant as you want the process of forming droplets and evaporating solvent to be the same, day after day and at different locations with different circumstances. An important parameter in this reproducibility is the gas flow. By using Mass Flow Controllers for Nebulizer gas and Evaporation or Drying gas, the ion source will always have reproducible gas flows.
Our solutions department can design compact gas modules for analytical applications to supply gases for ion-source combined with other gas flows with high accuracy and good reproducibility. Combining components like pressure switches and/or shut-off valves with the flow channels can give a compact gas handling module to fit in the small footprint demanding designs of the Mass Spectrometers. Furthermore, the changes on leaks are decreased significantly as the whole manifold can be leak and pressure tested before it is shipped to the customer.
If you would like to learn more about Bronkhorst customized flow solutions, you can watch this video or visit our on our solutions page.
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