We offer the widest product range of low-flow (mass) flow meters and controllers on the market. Numerous styles of both standard and bespoke instruments can be offered for applications in laboratory, machinery, industry and hazardous areas.
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Bronkhorst instruments are used for numerous applications in many different markets. In this section you will find an overview of the main markets for our equipment, illustrated with some typical examples of applications.
Are you looking for technical documentation, are you interested to learn more about the measuring principles of Bronkhorst products, or you do want to get in contact with a Bronkhorst Service Engineer? This section will guide you to the relevant service & support topics.
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Coriolis mass flow meters combined with WADose high pressure pumps are used for precise dosing of pharmaceutical agents. Combining this flow meter with a high-pressure pump allows you to dose very small amounts of pharmaceutical agent in a liquid state very reproducible.
Precise dosing of pharmaceutical agents
In this application the objective is to investigate the effect of newly developed medicines. To this end, liquid pharmaceutical agents are supplied into a blood vessel of lab test species. In order to determine exact conversion rates of the medicines and therefore their influence on the test species, reproducible and precise dosing is required. Lack of dosing precision is a typical obstacle for the repeatability of such experiments.
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In this application precise dosing is essential. The dosing flow meter/pump combination should exhibit a very low pulsation at ultra-low flow rates in order not to harm the fragile cell tissue of the test species. The dosing pump needs to be easy to clean and to disinfect to avoid contamination. Stable temperature conditions are necessary, as temperature changes will influence the transition rates of the chemical compounds and their biochemical conversion by enzymes.
To dose these ultra-low flows of pharmaceutical agent (in a liquid state) very precisely, a Coriolis mass flow meter and a WADose HP Lite pump are used. The flow meter controls the pump, meaning the pump builds up the pressure and delivers the requested flow.
Due to variable fluid properties and small leaks that are present in the pump head, it is difficult for the pump as a stand-alone device to deliver the desired ultra-low flow. In the combined setup, the mass flow meter measures the flow in real-time, and controls the pump by adjusting the flow.
Simply ‘plug & play’ the flow meter/pump combination to get started.
In order not to harm the species’ tissue, the pulsation of the pump is significantly reduced by using a special pulsation damper. A heat exchanger attached around the pump head is used to maintain a stable temperature of the pharmaceutical agents.
Pharmaceutical agents often have a high salt concentration which the flow meter/pump combination must deal with. ‘Easy to clean’ devices are therefore a must. The WADose high pressure pump is easy to clean to avoid contamination. It even has an option for seal wash. It increases the pumps’ lifetime and minimises possible downtime.
A traditional way to supply these medicines has been by using a simple syringe or syringe pump. However, a syringe pump lacks exact control over the actual dose of agent. By combing a high-pressure pump with a Coriolis flow meter, you can have this exact control, and therefore, have influence on the actual dose of agent and have a precise dosing solution.